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KMID : 0379520030190010021
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한국독성학회지
2003 Volume.19 No. 1 p.21 ~ p.27
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A Teratogenicity Study on Dimethyl Dimethoxy Biphenylate Derivative (DDB-S) in Rats
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Kim Hyun-Woo
Park Jin-Hong
Moon Seo-Hyun
Eu Gook-Jong
Kim Hwa
Kim J.-S.
Park Jong-Ha
Cho Hyun-Sun
Kang Ka-Mi
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Abstract
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A teratogenic study of dimethyl dimethoxy biphenylate derivative (DDB-S) was carried out on Sprague-Dawley rats. DDB-S dissolved in saline was administered to male and female rats by intravenously injection at daily doses of 50 mg/kg, 75 mg/kg, and 100 mg/kg. A half of dams were sacrificed at 20th day of gestation to scrutinize the pregnant performances and fetal development. And the remaining dams were allowed to deliver. The growth, reflex, behaviour and reproductive function of F1 offsprings were examined. There was no treatment-related difference in body weight, food consumption and necropsy findings of dams. No gross, skeletal and visceral abnormalities was observed in F1 fetuses from dams treated with DDB-S. F1 offsprings did not show any treatment-related difference in growth, reflex, behaviour and reproductive performance. At caesarean section of F1 dams, no growth retardation and gross abnormality was observed in F2 fetuses. In conclusion, DDB-S did not show any potential teratogenic effect in rats.
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KEYWORD
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Dimethyl dimethoxy biphenylate derivative (DDB-S), Teratogenic study, Rats
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